✍🏽 Welcome to Landon’s Loop: your go-to weekly read on Chicago startups, funding, and innovation.
In this week’s newsletter #105:
- Chicago-based Abbott expands its Illinois footprint
- Argonne National Lab’s push to integrate AI into nuclear ops
- This week’s top Chicago tech events
You can read my post here on why being a transplant to Chicago has become an advantage 👇🏽
Four standout demos last week, including tools for epilepsy support and smarter surveys. Plenty of fresh faces in the room too. If you’re interested in sponsoring Chicago’s top AI meetup learn more here 👇🏽
We talked about how AI can make Web3 easier to use + how blockchain can help secure data and ownership in an agent-led future. Big thanks to ETHChicago for hosting a great discussion 👇🏽
One of Chicago’s most iconic healthcare companies, Abbott is adding 200 new R&D roles, which will strengthen our region’s rep as a hub for life sciences innovation and high-skilled jobs 👇🏽
Chicago-based @AbbottNews is investing $500m in Illinois and Texas.
The Illinois facility alone will add 200 new jobs and expanded R&D.
— Landon (@landon20s)
2:28 PM • Apr 16, 2025
In a lab just outside Chicago, Argonne scientists are giving AI the ability to understand nuclear reactors from the inside out.
The project, PRO-AID, uses explainable AI and automated reasoning to bring aging reactors into the digital era. As AI demand increases and plants grow older, I believe LLM use-cases like this are key to keeping critical infrastructure online.
A few weeks back, I wrote about why Argonne exists. Now, let’s get into the details of their latest AI-powered nuclear project:
Most US nuclear reactors were built over 40 years ago, long before digital systems. PRO-AID (short for Parameter-Free Reasoning Operator for Automated Identification and Diagnosis) is built for this challenge.
It reads plant diagrams, builds a digital twin, and monitors real-time sensor data. If something goes off, it flags the issue and diagnoses it using logic-based reasoning.
No human intervention needed.
Argonne plans to offer PRO-AID to new, tech-forward nuclear builds. As companies like Amazon and Microsoft look to reactivate older plants to power data centers, smarter monitoring will be essential.
With global data center energy use expected to more than double by 2030, systems like PRO-AID can help these plants stay online and operate safely.
What makes PRO-AID different is its ability to explain itself. It mimics the thought process of veteran operators, tracing problems through cause and effect, and uses LLMs to translate that logic into plain language.
The nuclear industry is facing a talent crunch. Nuclear engineering degrees have dropped 27% since 2016. Many skilled workers are retiring, and not enough are entering the field.
Midwest schools like UIUC, Michigan, and Purdue are still producing strong talent, but it's not enough.
PRO-AID helps fill the gap. It turns decades of expertise into software that trains new workers and keeps plants running smoothly. For older reactors, this is a necessary future.
Here’s a cool video explaining more on PRO-AID:
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The Composable Conference by the MACH Alliance
Monday and Tuesday
Event Marketing University
Tuesday
Energy and Sustainability Tech Meetup
Tuesday
Beyond the Algorithm - The Environmental Impact of AI
Tuesday
The Future of Diagnostics
Tuesday
Building Agentic AI: The Future of Autonomous Business
Tuesday
Facilitation Lab Chicago
Tuesday
Chicago Data Night
Hosted by Drive Capital and UChicago
1 Million Cups Chicago
Wednesday
FaithTech Chicago Relaunch
Thursday
Kudos to @susanamendoza10. Turned the Illinois Rainy Day Fund from a shocking $48K to $2.3B over 7ish years.
This is fiscal discipline in action.
— Landon (@landon20s)
3:56 PM • Apr 17, 2025